Programmed Electrical Stimulation in Mice

Programmed electrical stimulation--before when, how?

Risk Stratification in Brugada Syndrome: Role of Programmed Electrical Stimulation

Brugada syndrome (BS) is an arrhythmogenic disease characterized by a typical electrocardiographic finding (type 1 Brugada electrocardiogram [ECG]) and an increased risk for sudden cardiac death (SCD) due to polymorphic ventricular tachycardia or ventricular fibrillation (VF). Risk stratification remains a challenge, especially in cases without documented cardiac arrest or VF. The role of progr...

Monophasic action potential duration during programmed electrical stimulation.

UNLABELLED To examine changes in monophasic action potential duration (APD) with a pacing protocol similar to that used during electrophysiological testing, action potentials were recorded in vivo from the left ventricular apical endocardium of 12 normal mongrel dogs. The atrioventricular node was ablated and the dogs paced from the anterior right ventricle at a baseline cycle length of 1000 ms...

Effects of subretinal electrical stimulation in mer-KO mice.

PURPOSE Subretinal electrical stimulation (SES) from microphotodiode arrays protects photoreceptors in the RCS rat model of retinitis pigmentosa. The authors examined whether mer(kd) mice, which share a Mertk mutation with RCS rats, showed similar neuroprotective effects from SES. METHODS Mer(kd) mice were implanted with a microphotodiode array at postnatal day (P) 14. Weekly electroretinogra...

Prognostic value of programmed electrical stimulation in Brugada syndrome: 20 years experience.

BACKGROUND The prognostic value of electrophysiological investigations in individuals with Brugada syndrome remains controversial. Different groups have published contradictory data. Long-term follow-up is needed to clarify this issue. METHODS AND RESULTS Patients presenting with spontaneous or drug-induced Brugada type I ECG and in whom programmed electric stimulation was performed at our in...